Oligonucleotides possessing zwitterionic moieties
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United States of America Patent
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Jan 25, 2000
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N/A
app pub date -
Feb 10, 1992
filing date -
Feb 10, 1992
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Abstract
An oligonucleotide wherein at least one nucleotide unit includes a phosphonate moiety having the following structural formula: ##STR1## , wherein X is a zwitterionic moiety. Such oligonucleotides have improved cellular uptake capabilities and improved resistance against nuclease activity.
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