Antitumor antisense oligonucleotides

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United States of America Patent

PATENT NO 6018042
SERIAL NO

08914961

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Abstract

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The invention relates to deoxyribo- and ribo-oligonucleotides and derivatives thereof, as well as pharmaceutical preparations, therapies, diagnostics and commercial research reagents in relation to disease states which respond to modulation of the synthesis of the enzyme S-adenosylmethionine decarboxylase (SAMDC). In particular, the invention relates to antisense oligonucleotides and oligonucleotide derivatives specifically hybridizable with nucleic acids relating to (preferably human) SAMDC. These oligonucleotides and their derivatives have been found to modulate the synthesis of SAMDC in cells.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS AGLICHTSTRASSE 35 BASEL 4056

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dean, Nicholas Mark Cardiff by the Sea, CA 2 25
Haner, Robert Fehren, CH 7 78
Mett, Helmut Neuenburg, DE 7 121

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