Nucleic acid ligands that bind to and inhibit DNA polymerases
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United States of America Patent
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Feb 1, 2000
Issued Date -
N/A
app pub date -
Oct 28, 1997
filing date -
Jun 7, 1995
priority date (Note) -
Expired
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Abstract
This invention discloses high-affinity oligonucleotide ligands to the thermostable Taq polymerase and Tth polymerase. Specifically, this invention discloses DNA ligands having the ability to bind to the Taq and Tth polymerases and the methods for obtaining such ligands. The ligands are capable of inhibiting polymerases at ambient temperatures.
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