Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
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United States of America Patent
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Feb 8, 2000
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N/A
app pub date -
Mar 6, 1998
filing date -
Mar 6, 1998
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Abstract
An apparatus and a method for electroporating tissue. At least one micropore is formed to a predetermined depth through a surface of the tissue, and electrical voltage is applied between an electrode electrically coupled to the micropore and another electrode spaced therefrom. By applying electroporation to tissue that has been breached by a micropore, the electroporation effects can be targeted at tissue structures beneath the surface, such as capillaries, to greatly enhance the withdrawal of biological fluid, and the delivery for uptake of compounds into the tissue. In a preferred embodiment, a device is provided having elements that are suitable for microporating the tissue and which serve as the electroporation electrodes.
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