Transgenic non-human animals depleted in a mature lymphocytic cell-type
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United States of America Patent
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Feb 8, 2000
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N/A
app pub date -
Dec 5, 1996
filing date -
Dec 5, 1988
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Abstract
Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprised is a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.
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