Antibody-based method of localizing activated thrombin receptors
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United States of America Patent
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Feb 15, 2000
Issued Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Feb 19, 1991
priority date (Note) -
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Abstract
The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at cell surfaces and is useful in assay systems both for the detection of thrombin and for the evaluation of candidate thrombin agonists and antagonists. Further, the elucidation of the structure of the thrombin receptor permits the design of agonist and antagonist compounds which are useful diagnostically and therapeutically. The availability of the thrombin receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof which are also useful diagnostically or therapeutically.
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