Receptor specific transepithelial transport of therapeutics
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United States of America Patent
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Feb 29, 2000
Issued Date -
N/A
app pub date -
Jul 24, 1997
filing date -
Jan 17, 1995
priority date (Note) -
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Abstract
The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
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