7-amino-2-heptenoates and their use in the preparation of methylphenidate

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United States of America Patent

PATENT NO 6031124
SERIAL NO

09155322

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Abstract

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The subject invention pertains to compounds of the formula Y.sup.1 Y.sup.2 N--(CH.sub.2).sub.4 --CH.dbd.C(Ph)--X wherein Y.sup.1 and Y.sup.2 are independently H or a removable blocking group, or Y.sup.1 and Y.sup.2 together are a removable divalent blocking group; and X is COOCH.sub.3 or a group convertible thereto. Such a compound may be cyclised, by Michael addition, to give methylphenidate, if necessary after removing blocking group(s) and converting X to COOCH.sub.3. The subject invention also pertains to methods for preparing compounds of the invention.

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Patent Owner(s)

  • CELLTECH PHARMA EUROPE LIMITED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fox, Martin Edward Cambridge, GB 11 10
Paul, Jane Marie Cambridge, GB 5 6

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