Method for covalent attachment of biomolecules to surfaces of medical devices

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United States of America Patent

PATENT NO 6033719
SERIAL NO

09012056

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. The method may include combining a biomolecule comprising a 1,2 dicarbonyl moiety with a material comprising a guanidino moiety to form an immobilized biomolecule on a medical device biomaterial surface through covalent bonds. Another method of the present invention may include combining a biomolecule comprising a guanidino moiety with a material comprising a 1,2 dicarbonyl moiety to form an immobilized biomolecule on a medical device biomaterial surface through covalent bonds. Additionally, one method of the present invention may be employed to crosslink biomolecules, located in solution or on a medical device biomaterial surface, thereby forming a crosslinked biomaterial or a crosslinked medical device coating.

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Patent Owner(s)

Patent OwnerAddress
MEDTRONIC INC710 MEDTRONIC PARKWAY NE MAIL STOP LC340 MINNEAPOLIS MN 55432

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Keogh, James R Maplewood, MN 138 22111

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