Production of polyketides in bacteria and yeast

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United States of America Patent

PATENT NO 6033883
SERIAL NO

08989332

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Abstract

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Hybrid and novel polyketide synthases and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of improved libraries of PKS and polyketides. In addition, polyketides can be produced in hosts that ordinarily do not produce polyketides by supplying, along with an expression system for the desired PKS, an expression system for holo ACP synthase.

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Patent Owner(s)

Patent OwnerAddress
BIOTICA TECHNOLOGY LIMITEDCHESTERFORD RESEARCH PARK LITTLE CHESTERFORD NR SAFFRON WALDEN ESSEX CB10 1XL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ashley, Gary W Alameda, CA 34 432
Barr, Philip J Oakland, CA 80 1320
Santi, Daniel V San Francisco, CA 66 1488
Ziermann, Rainer San Mateo, CA 12 156

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