Double-stranded oligonucleotide and anticancer agent containing the same as active ingredient
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United States of America Patent
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Mar 7, 2000
Grant Date -
N/A
app pub date -
Jul 17, 1996
filing date -
Nov 17, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention provides a double-stranded oligonucleotide or a derivative thereof which comprises 15 to 40 base pairs, wherein at least one side of the strands contains at least one nucleotide sequence represented by 5'-TTTSSCGS-3' (S is G or C). Also, since the compound of the present invention can inhibit expression of growth-related genes which are regulated by E2F, through its function to undergo sequence-specific competitive inhibition of the binding of E2F protein to the transcription region at a low concentration, a pharmaceutical composition containing the inventive compound as its active ingredient is useful as a drug having low side effects for use in the prevention and treatment of cancers.
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