Non-lethal conditioning methods for the treatment of acquired immunodeficiency syndrome
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United States of America Patent
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Mar 21, 2000
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N/A
app pub date -
Dec 11, 1997
filing date -
Dec 11, 1997
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Expired
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Abstract
The present invention relates to the use of a non-lethal preparative regimen for the treatment of a patient with human immunodeficiency virus (HIV) disease. In a clinical trial, an HIV-positive patient was conditioned by non-lethal doses of irradiation and a chemotherapeutic drug prior to receiving donor bone marrow cells from a baboon. While long-term engraftment of donor cells was not observed, the non-lethal preparative conditioning regimen was able to reduce the viral burden and improved the clinical outcome. Such method is useful for treatment of patients with advanced acquired immunodeficiency syndrome (AIDS).
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