Effect of electric field and ultrasound for transdermal drug delivery
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United States of America Patent
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Mar 21, 2000
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N/A
app pub date -
Apr 1, 1996
filing date -
Dec 18, 1995
priority date (Note) -
Expired
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Abstract
Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by application of an electric field, for example, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layers of the stratum corneum (SC). This method provides higher drug transdermal fluxes, allows rapid control of transdermal fluxes, and allows drug delivery or analyte extraction at lower ultrasound intensities than when ultrasound is applied in the absence of an electric field.
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