Apo-2 ligand

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United States of America Patent

PATENT NO 6046048
SERIAL NO

08780496

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Abstract

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A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.

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Patent Owner(s)

Patent OwnerAddress
GENENTECH INC1 DNA WAY SOUTH SAN FRANCISCO CA 94080-4990

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ashkenazi, Avi J San Mateo, CA 317 2941
Chuntharapai, Anan Colma, CA 83 916
Kim, Kyung Jin Los Altos, CA 138 1460

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