Prostate cancer drug screening using hKLK2 enhancer

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United States of America Patent

PATENT NO 6051417
SERIAL NO

08906192

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Abstract

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Screening of compounds for activity toward inhibition of prostate cancer cell proliferation is provided. A cell line containing an expression construct comprising a transciptional initiation region of a prostate specific enhancer from a human glandular kallikrein (hKLK2) gene is employed which can be used in conventional equipment for determining activity of compounds, where the cell line uses a marker whose expression is responsive to therapeutically active compounds.

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Patent Owner(s)

  • CELL GENESYS, INC.;NORTHERN TELECOM LIMITED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Henderson, Daniel R Palo Alto, CA 50 630
Lamparski, Henry G San Mateo, CA 5 9
Schuur, Eric R Cupertino, CA 17 182
Yu, De-Chao Foster City, CA 19 225

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