.alpha.1-6 fucosyltransferase
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United States of America Patent
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Apr 25, 2000
Grant Date -
N/A
app pub date -
Jan 7, 1998
filing date -
Jan 24, 1996
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Abstract
Porcine- or human-derived .alpha.1-6 fucosyltransferases having the following action: action: transferring fucose from guanosine adiphosphate-fucose to the hydroxy group at 6-position of GlcNAc closest to R of a receptor (GlcNAc.beta.1-2Man.alpha.1-6)(GlcNAc.beta.1-2Man.alpha.1-3)Man.beta.1-4GlcNAc.beta.1-4GlcNAc-R wherein R is an asparagine residue or a peptide chain carrying said residue, whereby to form (GlcNAc.beta.1-2Man.alpha.1-6)-(GlcNAc.beta.1-2Man.alpha.1-3)Man.beta.1-4GlcNAc.beta.1-4(Fuc.alpha.1-6)GlcNAc-R; a gene encoding these enzymes; an expression vector containing the gene; a transformant prepared by using this expression vector; and a method for producing a recombinant .alpha.1-6 fucosyltransferase, by culturing the transformant.
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