Down-regulation of DNA repair to enhance sensitivity to P53-mediated apoptosis
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United States of America Patent
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Apr 25, 2000
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app pub date -
Jul 5, 1996
filing date -
Jul 5, 1996
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Expired
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Abstract
The present invention details methods for the treatment of cancer. In particular it concerns the induction of apoptosis in cancer cells following treatment with inhibitors of DNA repair in combination with p53. Treatment of glioblastoma and breast tumor cells with inhibitors of DNA repair induced growth suppression that was a result of p53-mediated apoptosis. Thus it appears that inhibitors of DNA repair in combination with p53 is involved in restoration of p53-mediated apoptosis.
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