Stabilized thyroid hormone preparations and methods of making same

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United States of America Patent

PATENT NO 6056975
SERIAL NO

09156844

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Abstract

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Disclosed are thyroid hormone preparations useful in pharmaceutical applications. These preparations are disclosed to contain thyroxine drugs in combination with an inorganic salt, a carbohydrate having a molecular weight of greater than 500, and glycine. The preparations are also disclosed to have a free water content less than 4.5% by weight of the preparation. Also provided are compositions containing a reduced carbohydrate, a water soluble polysaccharide, or galactose. The preparations have improved stability wherein they are provided as being stable to the extent that substantially no potency loss is measured when the preparation is stored at 40.degree. C. and 75% relative humidity for 3 months.

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Patent Owner(s)

Patent OwnerAddress
ABBVIE DEUTSCHLAND GMBH & CO KGMAINZER STR 81 WIESBADEN 65189

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mitra, Amit K Silver Spring, MD 4 449
Srinivas, Raghunath Barrington, IL 3 92
Thomas, III Charles L Keithsville, LA 2 85

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