Antisense nucleic acid compounds inhibiting vascular endothelial growth factor
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United States of America Patent
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May 2, 2000
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N/A
app pub date -
Jul 21, 1998
filing date -
Jul 25, 1997
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Expired
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Abstract
The present invention provides an antisense nucleic acid compound inhibiting expression of vascular endothelial growth factor as well as therapeutic and diagnostic agents comprising the same as an active ingredient. A compound which nucleotide sequence is substantially complementary to a nucleotide sequence located upstream of a translation region in a gene coding for vascular endothelial growth factor and which inhibits 50% or more of the expression of vascular endothelial growth factor in cells is used as the antisense nucleic acid.
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