Pulmonary delivery of pharmaceuticals
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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-
May 9, 2000
Issued Date -
N/A
app pub date -
May 1, 1998
filing date -
May 20, 1991
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
In a method for treating lung diseases, a drug formulation is prepared by combining micronized crystalline beclomethasone dipropionate and lactose. The drug formulation is placed into a dry powder inhaler which provides inhalable drug particles having a mass median diameter of about 0.5-5.8 microns. The inhaler is preferably largely flow rate independent. Drug and lactose particles are separated in the inhaler during inhalation, most desirably via a spinning element. Due to deep deposition, the drug particles persist in the lungs for a surprisingly long duration, increasing the therapeutic effect of each dose. The patient inhales the drug particles with an inspiratory flow rate of about 10-60 liters/minute, to produce a deep lung deposition of inhaled particles.
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