Process for the production of hetero-bispecific antibodies
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United States of America Patent
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May 9, 2000
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N/A
app pub date -
Mar 22, 1990
filing date -
Mar 23, 1989
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Abstract
For the production of hetero-bispecific monoclonal antibodies at least the genes for the light chain and for the variable part of the heavy chain are isolated from a hybridoma cell line which secretes an antibody with a desired specificity and they are inserted into a eukaryotic plasmid vector which contains a marker capable of selection together with a strong promoter, this expression vector is transfected into a hybridoma cell line which secretes antibodies with a second desired specificity, the cell line is cultured, the antibodies are obtained and the bispecific antibody is isolated.
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