Inhibition of viral replication
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United States of America Patent
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May 9, 2000
Grant Date -
N/A
app pub date -
Sep 3, 1997
filing date -
Sep 3, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to methods and compositions for inhibition of viral replication in animal cells. In particular, inhibition of viral replication in a target cell is achieved by introducing into the cell (1) a protein which can be incorporated along with wild type nucleocapsid subunits into a viral nucleocapsid assembling within the cell, and thereby renders the nucleocapsid deficient in encapsidating viral nucleic acid; or (2) a recombinant nucleic acid construct that directs overexpression of the protein.
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