Process for oligonucleotide synthesis
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United States of America Patent
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May 30, 2000
Grant Date -
N/A
app pub date -
Oct 6, 1998
filing date -
Oct 6, 1998
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Abstract
The present invention describes methods for linking phosphoramidite nucleosides to a solid support-bound nucleoside. This invention presents novel processes for synthesizing oligonucleotides. Acetonitrile having a water content between 30 ppm and about 1250 ppm is used as the solvent for the washing steps in solid phase oligonucleotide synthesis, or is used as a solvent for the capping reagent or oxidizing reagent. The processes of the present invention are amenable to large-scale, economic oligonucleotide synthesis using the phosphoramidite method.
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