Skin blister biopsy apparatus and method
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United States of America Patent
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-
Jun 6, 2000
Grant Date -
N/A
app pub date -
Jul 31, 1997
filing date -
Jul 21, 1996
priority date (Note) -
In Force
status (Latency Note)
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Abstract
A skin blister method and apparatus are disclosed to evaluate and quantify epidermal nerves by separating an epidermis sample. The method is useful for a variety of purposes including diagnosis of neuropathy or nerve injury from any cause; measurement of the time course and character of nerve regeneration with and without modifying influences; and measurement of the response of normal, abnormal or regenerating nerves to exposure to various types of chemical or physical modalities. The principle step in the process of the invention is the creation of a skin blister, preferably by means of negative pressure. The blister consists of the epidermis, its nerves and fluid. The epidermis is subsequently studied by one or more of a variety of processes. The apparatus of the invention comprises a capsule with a chamber which is connected to a gage, pump and connecting valves.
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