Stabilized conjugates of uncomplexed subunits of multimeric proteins
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United States of America Patent
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Jun 6, 2000
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app pub date -
Oct 15, 1997
filing date -
Oct 15, 1996
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Abstract
The present invention provides methods for preparing, and compositions comprising, stabilized protein-polymer conjugates. More particularly, the present invention relates to the stabilization of individual subunits of multisubunit protein complexes by conjugation to polymers. Such conjugation acts to stabilize the individual subunit in its native conformation in liquid medium, which in turn acts to stabilize its biological activity.
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