Methods for isolation and use of T cell epitopes eluted from viable cells in vaccines for treating cancer patients
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United States of America Patent
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Jun 20, 2000
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app pub date -
Jan 15, 1997
filing date -
Jan 29, 1993
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Abstract
Methods are provided for eluting peptides that are bound to major histocompatibility complex ('MHC') molecules expressed on the cell surfaces of viable cells that have at least one MHC-peptide complex on the surfaces of the cells. Methods are provided for using such acid-eluted T cell epitopes, preferably obtained from a patient's tumor, and autologous dendritic cells as the basis for antitumor vaccines.
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