Methods of identifying inhibitors of sensor histidine kinases through rational drug design
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United States of America Patent
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Jun 20, 2000
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N/A
app pub date -
Mar 19, 1998
filing date -
Mar 19, 1998
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Abstract
The present invention provides N-terminal truncated transmembrane sensor histidine kinases that retain their ability to be autophophorylated and/or their related histidine kinase activity. The N-terminal truncated transmembrane sensor histidine kinases are useful for obtaining detailed three-dimensional structural data of the catalytic portion of the protein. The three-dimensional structural data is included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the N-terminal truncated transmembrane sensor histidine kinases are also provided.
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