Cancer susceptibility mutations of BRCA1
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United States of America Patent
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-
Jul 4, 2000
Issued Date -
N/A
app pub date -
Dec 11, 1997
filing date -
Sep 25, 1995
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
New mutations have been found in the BRCA1 gene. The mutations are located at nucleotide numbers 421-2, 815, 903, 926, 1506, 2034, 2428, 3888, 3904, 4164, 4643, 5053, 5150, 5210, or 5396+40 of the gene sequence of BRCA1. A process for identifying a sequence variation in a BRCA1 polynucleotide sequence is disclosed. The identification process includes allele specific sequence-based assays of known sequence variations. The methods can be used for efficient, and accurate detection of a mutation in a test BRCA1 gene sample.
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