Reagentless analysis of biological samples

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United States of America Patent

PATENT NO 6087182
SERIAL NO

09141483

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Abstract

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Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e.g, urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.

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Patent Owner(s)

Patent OwnerAddress
ABBOTT LABORATORIESD-377 ABBOTT PARK IL 60064 U S A

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jeng, Tzyy-Wen Vernon Hills, IL 19 1729
McDowell, Larry L Beach Park, IL 8 724
Oosta, Gary M Gurnee, IL 14 1897
Pezzaniti, Joseph Larry Round Lake, IL 11 947
Shain, Eric B Glencoe, IL 49 9451

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