Enhancement of ribozyme catalytic activity by A 2'-O-substituted facilitator oligonucleotide
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United States of America Patent
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Jul 11, 2000
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N/A
app pub date -
Mar 18, 1997
filing date -
Feb 4, 1992
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Abstract
Methods are disclosed for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme and a 2'-O-substituted facilitator oligonucleotide. The present invention further provides compositions comprising a ribozyme and an effective amount of a 2'-O-methyl substituted facilitator oligonucleotide. The use of a facilitator, particularly a 2'-O-substituted facilitator, and more especially a 2'-O-methyl substituted facilitator, greatly enhances ribozyme catalytic activity, frequently making an otherwise inactive ribozyme active.
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