Mice lacking expression of osteoprotegerin

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6087555
SERIAL NO

08943687

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed is a mouse in which expression of the gene encoding Osteoprotegerin is suppressed. Also disclosed is a nucleic acid construct useful in preparing such a mouse, and a cell line containing such construct.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
AMGEN INC.THOUSAND OAKS, CA871

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dunstan, Colin Newbury Park, CA 4 65
Sarosi, Ildiko Newbury Park, CA 4 79
Simonet, Scott Thousand Oaks, CA 2 71

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Patent Info (Count) # Cites Year
 
THE UNIVERSITY OF SHEFFIELD (1)
9334327 Pulmonary hypertension 0 2012
 
Other [Check patent profile for assignment information] (4)
* 2003/0100,488 OSTEOPROTEGERIN BINDING PROTEINS 19 1998
* 2004/0198,968 Novel human calcium dependent proteases, polynucleotides encoding the same, and uses thereof 0 2004
* 2005/0066,377 Arrayed collection of genomic clones 1 2004
* 2007/0009,520 Antibodies to OCIF-binding molecules 7 2006
 
SDGI HOLDINGS, INC. (1)
* 2002/0052,656 Expandable push-in interbody spinal fusion implant 27 2001
 
LEXICON GENETICS INCORPORATED (2)
6858419 Human kinases and polynucleotides encoding the same, and uses thereof 0 2001
6716614 Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof 5 2002
 
CEPHALON AUSTRALIA PTY LTD (1)
8530624 Osteoprotegerin variant proteins 0 2009
 
DAIICHI SANKYO COMPANY, LIMITED (11)
7527790 Methods of reducing bone absorption comprising administering an antibody that binds OBM 7 2002
* 2003/0176,647 Antibodies to OCIF-binding molecules 15 2002
6855808 Proteins and methods for producing the proteins 11 2002
7192718 Methods for identifying a substance which specifically binds to an osteoclastogenesis inhibitory factor-binding molecule and modulates the biological activity thereof 7 2003
* 2003/0208,045 Novel Protein and method for producing the protein 2 2003
7276344 Methods for using the osteoclastogenesis inhibitory factor (OCIF) protein 6 2004
7449185 Antibodies to OCIF-binding molecules 8 2004
* 2005/0003,457 Antibodies to OCIF-binding molecules 2 2004
7468268 Nucleic acid molecules encoding osteoclastogenesis inhibitory factor proteins 6 2004
* 2005/0208,580 Novel protein and method for producing the protein 7 2005
* 2008/0187,540 Antibodies to OCIF-binding molecules 1 2006
 
CEDARS-SINAI MEDICAL CENTER (4)
6909030 PTTG knockout rodent as a model to study mechanisms for various physiological phenomena, including diabetes 2 2001
7097829 Transgenic cells transfected with pituitary tumor transforming gene (PTTG)) expression vectors and uses therefor 0 2002
* 2003/0100,530 Transgenic cells transfected with pituitary tumor transforming gene (PTTG)) expression vectors and ues therefor 0 2002
* 2005/0177,887 Somatic cells, germ cells and cell lines derived from a PTTG knockout rodent 3 2005
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (3)
7259143 Method of extending the dose range of vitamin D compounds 3 2002
* 2004/0053,813 Method of extending the dose range of vitamin D compounds 0 2002
* 2008/0249,068 Method of Extending the Dose Range of Vitamin D Compounds 0 2007
 
CEPHALON AUSTRALIA (VIC) PTY LTD (2)
7612169 Osteoprotegerin variant proteins 1 2005
* 2006/0189,528 Osteoprotegerin variant proteins 4 2005
 
BAUSCH & LOMB INCORPORATED (1)
* 2008/0004,410 Hydrophilic macromonomers having alpha,beta-conjugated carboxylic terminal group and medical devices incorporating same 2 2006
 
ORACLE INTERNATIONAL CORPORATION (1)
* 2005/0216,471 System and method for analyzing content on a web page using an embedded filter 3 2004
 
Immunex Corporation (9)
7411050 Monoclonal blocking antibody to human RANKL 17 2004
* 2005/0003,391 Kits for detecting rankl proteins or nucleic acids 1 2004
7932375 Kits for detecting rank nucleic acids 5 2007
7790684 Method of inhibiting osteoclast activity 0 2008
7744886 Methods for interfering with rank signaling 8 2008
* 2009/0017,033 Methods for interfering with RANKL signaling 5 2008
8377690 Cells and methods for producing blocking antibodies to human RANKL 1 2010
8333963 Method of inhibiting osteoclast activity 0 2010
8715683 RANK ligand polypeptides 0 2013
 
E. R. SQUIBB & SONS, L.L.C. (5)
7718776 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 11 2003
* 2004/0023,313 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 32 2003
8367063 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 0 2010
* 2011/0052,604 Human Anti-OPGL Neutralizing Antibodies as Selective OPGL Pathway Inhibitors 1 2010
8455629 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 0 2012
 
SANKYO COMPANY, LIMITED (4)
* 2004/0142,426 Novel proteins and methods for producing the proteins 0 2004
* 2005/0014,229 Novel proteins and methods for producing the proteins 0 2004
* 2005/0124,054 Novel proteins and methods for producing the proteins 0 2004
* 2005/0118,682 Novel proteins and methods for producing the proteins 0 2004
 
RENESAS ELECTRONICS CORPORATION (1)
* 2004/0140,544 Semiconductor device 0 2003
 
AMGEN INC. (3)
7807795 Antibodies to osteoprotegerin binding proteins 1 1998
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7923008 Methods for decreasing osteoclast formation or bone resorption using an antibody to osteoprotegerin binding protein 4 2006
 
Lexicon Pharmaceuticals, Inc. (1)
7374932 Human kinases and polynucleotides encoding the same, and uses thereof 0 2004
 
WARSAW ORTHOPEDIC, INC. (60)
6500205 Expandable threaded arcuate interbody spinal fusion implant with cylindrical configuration during insertion 241 2000
7115143 Orthopedic implant surface configuration 32 2000
6814756 Expandable threaded arcuate interbody spinal fusion implant with lordotic configuration during insertion 128 2000
7008453 Expandable push-in arcuate interbody spinal fusion implant with cylindrical configuration during insertion 133 2000
6709458 Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion 149 2001
6808537 Expandable implant with interlocking walls 174 2001
6652584 Expandable threaded arcuate interbody spinal fusion implant with lordotic configuration during insertion 111 2001
6962606 Expandable push-in interbody spinal fusion implant 201 2001
* 2003/0208,270 Expandable push-in interbody spinal fusion implant 11 2001
7118579 Instrumentation for inserting an expandable interbody spinal fusion implant 168 2002
* 2002/0177,897 Instrumentation and method for inserting and deploying and expandable interbody spinal fusion implant 75 2002
6716247 Expandable push-in interbody spinal fusion implant 243 2002
7118598 Expandable push-in arcuate interbody spinal fusion implant with cylindrical configuration during insertion 133 2002
6972035 Expandable threaded arcuate interbody spinal fusion implant with cylindrical configuration during insertion 149 2002
* 2003/0100,949 Expandable threaded arcuate interbody spinal fusion implant with cylindrical configuration during insertion 34 2002
8075621 Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion 38 2003
6793679 Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion 146 2003
* 2004/0059,419 Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion 21 2003
7244275 Orthopedic implant surface configuration with a projection having a back cut 68 2003
* 2005/0021,150 Orthopedic implant surface configuration with a projection having a back cut 29 2003
7655027 Method for inserting and deploying an expandable interbody spinal fusion implant 93 2003
7399301 Instrumentation for use with dynamic single-lock anterior cervical plate system having non-detachably fastened and moveable segments 28 2004
7051417 Method for forming an orthopedic implant surface configuration 42 2004
* 2004/0181,229 Instrumentation for use with dynamic single-lock anterior cervical plate system having non-detachably fastened and moveable segments 19 2004
7115130 Method for installing dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments 48 2004
7112202 Method for installing dynamic, modular, single-lock anterior cervical plate system having assembleable and moveable segments 74 2004
* 2004/0186,476 Method for installing dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments 16 2004
* 2004/0181,226 Method for installing dynamic, modular, single-lock anterior cervical plate system having assembleable and moveable segments 29 2004
8444692 Instrumentation with inwardly moveable extensions for inserting an expandable interbody spinal fusion implant 4 2004
7922729 Instrumentation for inserting and deploying an expandable interbody spinal fusion implant 66 2004
* 2005/0015,149 Instrumentation with inwardly moveable extensions for inserting an expandable interbody spinal fusion implant 112 2004
* 2005/0010,294 Instrumentation for inserting and deploying an expandable interbody spinal fusion implant 35 2004
7811285 Dynamic, modular, single-lock anterior cervical plate system having assembleable and moveable segments and instrumentation for installation thereof 17 2004
* 2005/0027,297 Dynamic, modular, single-lock anterior cervical plate system having assembleable and moveable segments and instrumentation for installation thereof 62 2004
7803157 Dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments and instrumentation for installation thereof 21 2004
* 2005/0027,298 Dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments and instrumentation for installation thereof 65 2004
7824432 Method for installation of dynamic anterior cervical plate system having moveable segments 11 2004
* 2005/0085,816 Method for installation of dynamic anterior cervical plate system having moveable segments 92 2004
7608107 Expandable implant with interlocking walls and method for use thereof 111 2004
* 2005/0060,037 Expandable implant with interlocking walls and method for use thereof 32 2004
8097034 Expandable arcuate interbody spinal fusion implant with two expanders 32 2004
* 2005/0065,608 Expandable threaded arcuate interbody spinal fusion implant with lordotic configuration during insertion 59 2004
7621943 Method for installing dynamic multilock anterior cervical plate system having detachably fastened and moveable segments 18 2005
* 2005/0192,576 Method for installing dynamic multilock anterior cervical plate system having detachably fastened and moveable segments 43 2005
7704250 Instrumentation for use with dynamic multilock anterior cervical plate system having non-detachably fastened and moveable segments 20 2005
7547306 Method for installation of dynamic, single-lock anterior cervical plate system having non-detachably fastened and moveable segments 21 2005
* 2005/0216,010 Method for installation of dynamic, single-lock anterior cervical plate system having non-detachably fastened and moveable segments 34 2005
7892286 Expandable push-in orthopedic implant 50 2005
* 2006/0069,442 Expandable push-in orthopedic implant 37 2005
8007534 Expandable implant with expander 36 2005
* 2006/0079,962 Expandable implant with expander 28 2005
8771358 Expandable push-in arcuate orthopedic implant 4 2006
* 2007/0032,871 Expandable push-in arcuate orthopedic implant 64 2006
7985224 Method for installation of dynamic, single-lock anterior cervical plate system having non-detachably fastened and moveable segments 7 2009
* 2009/0259,226 Method for installation of dynamic, single-lock anterior cervical plate system having non-detachably fastened and moveable segments 11 2009
8834533 Dynamic plate system having moveable segments 0 2010
* 2011/0054,528 Dynamic plate system having moveable segments 11 2010
9345584 Expandable push-in orthopedic implant 0 2011
* 2011/0137,420 EXPANDABLE PUSH-IN ORTHOPEDIC IMPLANT 23 2011
8771321 Method for loading a spinal implant 1 2013
* Cited By Examiner