US Patent No: 6,087,555

Number of patents in Portfolio can not be more than 2000

Mice lacking expression of osteoprotegerin

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Abstract

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Disclosed is a mouse in which expression of the gene encoding Osteoprotegerin is suppressed. Also disclosed is a nucleic acid construct useful in preparing such a mouse, and a cell line containing such construct.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
AMGEN INC.THOUSAND OAKS, CA860

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dunstan, Colin Newbury Park, CA 4 63
Sarosi, Ildiko Newbury Park, CA 4 73
Simonet, Scott Thousand Oaks, CA 2 69

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
* 2005/0066,377 Arrayed collection of genomic clones 1 2004
* 2007/0009,520 Antibodies to OCIF-binding molecules 7 2006
 
SDGI HOLDINGS, INC. (1)
* 2002/0052,656 Expandable push-in interbody spinal fusion implant 23 2001
 
LEXICON GENETICS INCORPORATED (2)
6,858,419 Human kinases and polynucleotides encoding the same, and uses thereof 0 2001
6,716,614 Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof 5 2002
 
CEPHALON AUSTRALIA PTY LTD. (3)
7,612,169 Osteoprotegerin variant proteins 1 2005
* 2006/0189,528 Osteoprotegerin variant proteins 2 2005
8,530,624 Osteoprotegerin variant proteins 0 2009
 
DAIICHI SANKYO COMPANY, LIMITED (11)
7,527,790 Methods of reducing bone absorption comprising administering an antibody that binds OBM 7 2002
* 2003/0176,647 Antibodies to OCIF-binding molecules 15 2002
6,855,808 Proteins and methods for producing the proteins 9 2002
7,192,718 Methods for identifying a substance which specifically binds to an osteoclastogenesis inhibitory factor-binding molecule and modulates the biological activity thereof 7 2003
* 2003/0208,045 Novel Protein and method for producing the protein 2 2003
7,276,344 Methods for using the osteoclastogenesis inhibitory factor (OCIF) protein 5 2004
7,449,185 Antibodies to OCIF-binding molecules 8 2004
* 2005/0003,457 Antibodies to OCIF-binding molecules 2 2004
7,468,268 Nucleic acid molecules encoding osteoclastogenesis inhibitory factor proteins 5 2004
* 2005/0208,580 Novel protein and method for producing the protein 7 2005
* 2008/0187,540 Antibodies to OCIF-binding molecules 1 2006
 
CEDARS-SINAI MEDICAL CENTER (2)
6,909,030 PTTG knockout rodent as a model to study mechanisms for various physiological phenomena, including diabetes 2 2001
7,097,829 Transgenic cells transfected with pituitary tumor transforming gene (PTTG)) expression vectors and uses therefor 0 2002
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (2)
7,259,143 Method of extending the dose range of vitamin D compounds 3 2002
* 2008/0249,068 Method of Extending the Dose Range of Vitamin D Compounds 0 2007
 
Immunex Corporation (9)
7,411,050 Monoclonal blocking antibody to human RANKL 14 2004
* 2005/0003,391 Kits for detecting rankl proteins or nucleic acids 1 2004
7,932,375 Kits for detecting rank nucleic acids 5 2007
7,790,684 Method of inhibiting osteoclast activity 0 2008
7,744,886 Methods for interfering with rank signaling 8 2008
* 2009/0017,033 Methods for interfering with RANKL signaling 5 2008
8,377,690 Cells and methods for producing blocking antibodies to human RANKL 1 2010
8,333,963 Method of inhibiting osteoclast activity 0 2010
8,715,683 RANK ligand polypeptides 0 2013
 
ORACLE INTERNATIONAL CORPORATION (1)
* 2005/0216,471 System and method for analyzing content on a web page using an embedded filter 1 2004
 
E. R. SQUIBB & SONS, L.L.C. (4)
7,718,776 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 11 2003
* 2004/0023,313 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 26 2003
8,367,063 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 0 2010
8,455,629 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 0 2012
 
SANKYO COMPANY, LIMITED (2)
* 2004/0142,426 Novel proteins and methods for producing the proteins 0 2004
* 2005/0014,229 Novel proteins and methods for producing the proteins 0 2004
 
RENESAS ELECTRONICS CORPORATION (1)
* 2004/0140,544 Semiconductor device 0 2003
 
AMGEN INC. (3)
7,807,795 Antibodies to osteoprotegerin binding proteins 1 1998
* 2003/0103,978 Selective binding agents of osteoprotegerin binding protein 25 2001
7,923,008 Methods for decreasing osteoclast formation or bone resorption using an antibody to osteoprotegerin binding protein 4 2006
 
LEXICON PHARMACEUTICALS, INC. (1)
7,374,932 Human kinases and polynucleotides encoding the same, and uses thereof 0 2004
 
WARSAW ORTHOPEDIC, INC. (53)
6,500,205 Expandable threaded arcuate interbody spinal fusion implant with cylindrical configuration during insertion 204 2000
7,115,143 Orthopedic implant surface configuration 25 2000
6,814,756 Expandable threaded arcuate interbody spinal fusion implant with lordotic configuration during insertion 86 2000
7,008,453 Expandable push-in arcuate interbody spinal fusion implant with cylindrical configuration during insertion 102 2000
6,709,458 Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion 108 2001
6,808,537 Expandable implant with interlocking walls 120 2001
6,652,584 Expandable threaded arcuate interbody spinal fusion implant with lordotic configuration during insertion 86 2001
6,962,606 Expandable push-in interbody spinal fusion implant 152 2001
* 2003/0208,270 Expandable push-in interbody spinal fusion implant 7 2001
7,118,579 Instrumentation for inserting an expandable interbody spinal fusion implant 132 2002
* 2002/0177,897 Instrumentation and method for inserting and deploying and expandable interbody spinal fusion implant 49 2002
6,716,247 Expandable push-in interbody spinal fusion implant 203 2002
7,118,598 Expandable push-in arcuate interbody spinal fusion implant with cylindrical configuration during insertion 100 2002
6,972,035 Expandable threaded arcuate interbody spinal fusion implant with cylindrical configuration during insertion 110 2002
* 2003/0100,949 Expandable threaded arcuate interbody spinal fusion implant with cylindrical configuration during insertion 22 2002
8,075,621 Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion 16 2003
6,793,679 Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion 120 2003
7,244,275 Orthopedic implant surface configuration with a projection having a back cut 54 2003
7,655,027 Method for inserting and deploying an expandable interbody spinal fusion implant 64 2003
7,399,301 Instrumentation for use with dynamic single-lock anterior cervical plate system having non-detachably fastened and moveable segments 22 2004
7,051,417 Method for forming an orthopedic implant surface configuration 34 2004
* 2004/0181,229 Instrumentation for use with dynamic single-lock anterior cervical plate system having non-detachably fastened and moveable segments 14 2004
7,115,130 Method for installing dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments 41 2004
7,112,202 Method for installing dynamic, modular, single-lock anterior cervical plate system having assembleable and moveable segments 66 2004
* 2004/0186,476 Method for installing dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments 12 2004
* 2004/0181,226 Method for installing dynamic, modular, single-lock anterior cervical plate system having assembleable and moveable segments 21 2004
8,444,692 Instrumentation with inwardly moveable extensions for inserting an expandable interbody spinal fusion implant 1 2004
7,922,729 Instrumentation for inserting and deploying an expandable interbody spinal fusion implant 32 2004
* 2005/0010,294 Instrumentation for inserting and deploying an expandable interbody spinal fusion implant 26 2004
7,811,285 Dynamic, modular, single-lock anterior cervical plate system having assembleable and moveable segments and instrumentation for installation thereof 10 2004
* 2005/0027,297 Dynamic, modular, single-lock anterior cervical plate system having assembleable and moveable segments and instrumentation for installation thereof 57 2004
7,803,157 Dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments and instrumentation for installation thereof 14 2004
* 2005/0027,298 Dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments and instrumentation for installation thereof 61 2004
7,824,432 Method for installation of dynamic anterior cervical plate system having moveable segments 6 2004
* 2005/0085,816 Method for installation of dynamic anterior cervical plate system having moveable segments 67 2004
7,608,107 Expandable implant with interlocking walls and method for use thereof 77 2004
* 2005/0060,037 Expandable implant with interlocking walls and method for use thereof 27 2004
8,097,034 Expandable arcuate interbody spinal fusion implant with two expanders 20 2004
* 2005/0065,608 Expandable threaded arcuate interbody spinal fusion implant with lordotic configuration during insertion 36 2004
7,621,943 Method for installing dynamic multilock anterior cervical plate system having detachably fastened and moveable segments 11 2005
7,704,250 Instrumentation for use with dynamic multilock anterior cervical plate system having non-detachably fastened and moveable segments 14 2005
7,547,306 Method for installation of dynamic, single-lock anterior cervical plate system having non-detachably fastened and moveable segments 14 2005
* 2005/0216,010 Method for installation of dynamic, single-lock anterior cervical plate system having non-detachably fastened and moveable segments 32 2005
7,892,286 Expandable push-in orthopedic implant 34 2005
8,007,534 Expandable implant with expander 25 2005
* 2006/0079,962 Expandable implant with expander 21 2005
8,771,358 Expandable push-in arcuate orthopedic implant 1 2006
* 2007/0032,871 Expandable push-in arcuate orthopedic implant 46 2006
7,985,224 Method for installation of dynamic, single-lock anterior cervical plate system having non-detachably fastened and moveable segments 3 2009
* 2009/0259,226 Method for installation of dynamic, single-lock anterior cervical plate system having non-detachably fastened and moveable segments 7 2009
8,834,533 Dynamic plate system having moveable segments 0 2010
* 2011/0054,528 Dynamic plate system having moveable segments 7 2010
8,771,321 Method for loading a spinal implant 0 2013
* Cited By Examiner