Flow electroporation chamber with electrodes having a crystalline metal nitride coating
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United States of America Patent
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Jul 18, 2000
Grant Date -
N/A
app pub date -
Dec 5, 1996
filing date -
Dec 5, 1996
priority date (Note) -
Expired
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Abstract
An improved electrode for use in generating an electrical field in a saline solution is provided. In particular, a continuous crystalline metal nitride coated electrode is provided for use in a variety of saline solution applications, such as in an electrophoresis device for separating proteins or nucleic acids or an electroporation apparatus for the encapsulation of biologically-active substances in various cell populations. A method and apparatus are provided for the encapsulation of biologically-active substances in red blood cells, characterized by an optionally automated, continuous-flow, self-contained electroporation system which allows withdrawal of blood from a patient, separation of red blood cells, encapsulation of a biologically-active substances in the cells, and optional recombination of blood plasma and the modified red blood cells thereby producing blood with modified biological characteristics.
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