Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
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United States of America Patent
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Jul 25, 2000
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app pub date -
Jun 20, 1997
filing date -
Jun 20, 1997
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Abstract
The present invention provides a crystallized Bactericidal Permeability-Increasing (BPI) protein; methods for x-ray diffraction analysis to provide x-ray diffraction patterns of sufficiently high resolution for three-dimensional structure determination of the protein, as well as methods for rational drug design, based on using amino acid sequence data and/or x-ray crystallography data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms; and atomic coordinates are provided yielding structural information on the lipid binding and lipid transport protein family that includes BPI, LBP, CETP and PLTP.
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