Substrates, particularly medical devices, provided with bio-active/biocompatible coatings
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United States of America Patent
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Aug 8, 2000
Issued Date -
N/A
app pub date -
Dec 11, 1998
filing date -
Feb 22, 1995
priority date (Note) -
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Abstract
Disclosed is a method of enhancing the biocompatibility of a substrate by providing the substrate with a continuous bio-active surface coating. This method includes applying to the substrate a first coating which includes an aqueous dispersion or emulsion of a polymer containing an organic acid functional group and an excess of a polyfunctional cross-linking agent which is reactive with the organic acid groups of the polymer. A continuous bio-active surface coating is then formed over the dried first coating by applying thereover a bio-active agent containing an organic acid functional group or metal salt thereof. The first and second coatings are then dried to covalently bond the organic acid functional groups of the bio-active agent to the polymer through the excess unreacted polyfunctional cross-linking agent.
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