Inhibitors of protein tyrosine kinases
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United States of America Patent
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Aug 8, 2000
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N/A
app pub date -
Oct 10, 1997
filing date -
Oct 10, 1997
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Expired
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Abstract
Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine kinases, for example pp60.sup.c-src. Methods are further provided for the use of these inhibitors in situations where the inhibition of a protein tyrosine kinase is indicated, for example, in the treatment of certain diseases in mammals, including humans.
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