Propofol formulation with enhanced microbial characteristics
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United States of America Patent
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-
Aug 8, 2000
Grant Date -
N/A
app pub date -
Apr 5, 1999
filing date -
Apr 5, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Formulations of intravenous anesthetic propofol emulsions are provided which contain sufficiently low concentrations of soybean oil to produce a stable emulsion and simultaneously provide reduced nutrients, which inhibit microbial growth thereby providing protection against accidental microbial contamination during long-term IV infusions. In addition to the inhibition of microbial growth due to a reduction of nutrients, the formulation exhibits unanticipated additional microbial inhibition due to an increased availability of propofol. The low concentration of soybean oil also provides a formulation that reduces the chances of fat overload when administered over an extended period of time to chronically ill patients.
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