US Patent No: 6,103,219
Number of patents in Portfolio can not be more than 2000
Pharmaceutical excipient having improved compressibility
Stats
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Aug 15, 2000
Issued date -
Dec 17, 1997
filing date -
08/992,073
serial no -
In Force
status
Importance
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Abstract
A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,585,115 Pharmaceutical excipient having improved compressability | 54 | 1995 | |
| 5,725,883 Pharmaceutical excipient having improved compressibility | 34 | 1995 | |
| 5,741,524 Sustained-release formulations utilizing pharmaceutical excipient having improved compressibility | 52 | 1996 | |
| 5,725,884 Pharmaceutical excipient having improved compressibility | 27 | 1996 | |
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| 4,744,987 Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation | 84 | 1987 | |
| 5,192,569 Fat-like bulking agent for aqueous foods comprising microcrystalline cellulose and a galactomannan gum | 66 | 1991 | |
| 5,441,753 Coprocessed particulate bulking and formulating AIDS: their composition, production, and use | 38 | 1994 | |
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| 5,019,397 Aqueous emulsion for pharmaceutical dosage form | 60 | 1988 | |
| 4,946,685 Cellulosic dosage form | 56 | 1988 | |
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| 4,533,674 Process for preparing a sugar and starch free spray-dried vitamin C powder containing 90 percent ascorbic acid | 35 | 1983 | |
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| 4,536,511 Medicaments containing muzolimine, their use and processes for their production | 11 | 1984 | |
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| 4,664,915 Compressed and formed alkaline component suitable for use in buffered aspirin product | 38 | 1986 | |
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| 5,462,747 Pharmaceutical sustained release matrix | 62 | 1995 | |
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| 5,560,926 Process for the production of an S-ibuprofen-containing tablet | 21 | 1994 | |
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| 5,441,731 Compounds | 12 | 1992 | |
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| 4,923,981 Use of parenchymal cell cellulose to improve comestibles | 40 | 1989 | |
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| 5,447,729 Multilamellar drug delivery systems | 42 | 1994 | |
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| 5,126,145 Controlled release tablet containing water soluble medicament | 96 | 1990 | |
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| 5,322,698 Process for the preparation of a tablet or dragee composition containing a heat-, light- and moisture-sensitive active ingredient having monoclinic crystal structure | 25 | 1992 | |
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| 4,810,516 Reduced calorie and reduced fat chocolate confectionery compositions | 61 | 1987 | |
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| 4,303,846 Sintered electrode in a discharge tube | 24 | 1980 | |
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| 4,910,023 Drug in combination with flavor masking agent and method for making same | 32 | 1988 | |
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| 4,721,709 Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions | 47 | 1984 | |