Methods for promoting wound healing and treating transplant-associated vasculopathy
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United States of America Patent
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Aug 15, 2000
Issued Date -
N/A
app pub date -
Oct 2, 1998
filing date -
Nov 25, 1992
priority date (Note) -
Expired
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Abstract
The present invention provides a method of promoting the closure of a wound in a patient. This method involves transferring exogenous iNOS to the region of the wound whereby a product of iNOS is produced in the region of the wound to promote the closure of the wound. The present invention also provides a method of transplanting a graft into a patient, which method involves transferring a vector comprising an iNOS expression cassette to cells associated with the graft and surgically incorporating the graft tissue into the patient. Upon expression of iNOS within the patient, a product of iNOS is produced in the region of the graft to attenuate vasculopathy in the region of the graft.
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