Modified glucose dehydrogenase
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United States of America Patent
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Aug 15, 2000
Grant Date -
N/A
app pub date -
Sep 4, 1997
filing date -
Mar 3, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides a modified pyrrolo-quinoline quinone glucose dehydrogenase (PQQGDH) enzyme protein which is modified to have a substrate specificity to glucose. The modified PQQGDH of the invention exhibits a high substrate specificity compared to the wild type PQQGDH, thus is useful in determining glucose concentration in clinical assays and food analyses. A gene coding for the modified PQQGDH and a glucose sensor comprising the modified PQQGDH are also disclosed.
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