Method for the synthesis of nucleotide or oligonucleotide phosphoramidites

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Aug 15, 2000
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app pub date
Feb 12, 1999
filing date
Dec 27, 1996

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Expired

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Abstract

The present invention presents novel methods for recovery of phosphoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a trihalophenoxydihalophosphorane with a H-phosphonate in the presence of an amine.

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Patent Owner	Address
ISIS PHARMACEUTICALS INC	2280 FARADAY AVENUE CARLSBAD CA 92008 UNITED STATES OF AMERICA

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C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....

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Inventor Name	Address	# of filed Patents	Total Citations
Cole, Douglas L	San Diego, CA	192	1362
Griffey, Richard H	Vista, CA	162	5753
Ravikumar, Vasulinga T	Carlsbad, CA	39	625

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Method for the synthesis of nucleotide or oligonucleotide phosphoramidites

Number of patents in Portfolio can not be more than 2000

United States of America Patent

09249528

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PATENT NO	6103891
SERIAL NO	09249528
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09249528

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