Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
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United States of America Patent
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Aug 15, 2000
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app pub date -
May 29, 1998
filing date -
May 29, 1998
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Abstract
A sample preparation method is disclosed for volatilization and mass spectrometric analysis of nonvolatile high molecular weight molecules. Photoabsorbing molecules having significant sublimation rates at room temperature under vacuum, and preferably containing hydroxy functionalities, are disclosed for use as matrices in matrix-assisted laser desorption/ionization mass spectrometry. The samples are typically cooled in the mass spectrometer to temperatures significantly below room temperature.
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