Polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
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United States of America Patent
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Aug 22, 2000
Issued Date -
N/A
app pub date -
Feb 1, 1999
filing date -
Nov 25, 1996
priority date (Note) -
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Abstract
Disclosed are bio-active coating compositions for polymeric substrates. In particular, a bio-active coating is described which is the reaction product formed by providing a polymer backbone with at least one free isocyanate group, wherein the isocyanate group is pendant from the polymer backbone. There is further provided a hydrophilic, amine-terminated spacer which has at least one amine group at its first and second ends. One of the amine groups of the spacer is reacted with one or more of the isocyanate groups on the polymer backbone in the presence of an optional catalyst agent. A bio-active agent is then covalently bonded onto an unreacted end of the spacer in the presence of a catalyst. Also disclosed are coating compositions for a substrate and methods of preparing same.
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