Method for the preparation of a viral vector by intermolecular homologous recombination
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United States of America Patent
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Aug 29, 2000
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N/A
app pub date -
Aug 1, 1996
filing date -
Dec 1, 1994
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Abstract
A recombinant adenoviral vector containing an exogenous DNA sequence insertion is prepared in a prokaryotic cell using homologous intermolecular recombination. The exogenous DNA sequence codes for a polypeptide of therapeutic interest for applications in gene therapy. The adenoviral vector may lack all or part of at least one region essential for replication.
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