Beneficial agent delivery system with membrane plug and method for controlling delivery of beneficial agents
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United States of America Patent
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Sep 5, 2000
Grant Date -
N/A
app pub date -
Jul 24, 1998
filing date -
Dec 30, 1997
priority date (Note) -
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status (Latency Note)
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Abstract
An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule containing a beneficial agent and an osmotic agent which swells on contact with water causing the release of the beneficial agent over time. The osmotic delivery system has a membrane plug which allows water to pass through the plug from an exterior of the capsule while preventing the compositions within the capsule from passing out of the capsule. A delivery rate for delivery of the beneficial agent from the implant capsule is controlled by varying a core diameter of the membrane plug within a constant diameter capsule. The membrane plug has a variable water permeation rate depending on an extent to which the membrane plug is constrained by the capsule walls.
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