Methods of dry powder inhalation
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United States of America Patent
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Sep 12, 2000
Grant Date -
N/A
app pub date -
Apr 24, 1997
filing date -
Apr 29, 1996
priority date (Note) -
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Abstract
A method for inhalation of a dry powder drug includes the steps of providing a dry powder drug composition having a drug particle size of from about 1-7 microns and a mass median aerodynamic diameter of the delivered aerosol of from about 3.5 to 5.5 microns. This composition is loaded into an inhaler which is generally flow rate independent, and with the inhaler having an inspiration flow resistance of about 0.12 to 0.21 (cmH.sub.2 O).sup.1/2 over the range of about 15-60 L/min. The patient inhales the drug composition from the inhaler with an inspiration flow rate of about 15-60 L/min, resulting in a delivery efficiency measured by respirable fraction greater than 20%.
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