Process for making a bioprosthetic device and implants produced therefrom
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United States of America Patent
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Sep 12, 2000
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N/A
app pub date -
Aug 18, 1997
filing date -
Aug 18, 1997
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Abstract
Bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided as well as methods for their formation. The methods comprise combining an epoxy functionalized crosslinking agent with the collagen-based material in an aqueous medium at an acidic pH to react a portion of the collagen carboxyl groups with the epoxy functionalized crosslinking agent to form crosslinked collagen-based material comprising residual collagen carboxyl groups.
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