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Abstract

A compound useful as an A.sub.1 adenosine receptor antagonist has the formula: ##STR1## wherein R.sub.1 is selected from the group consisting of C.sub.1 -C.sub.8 alkyl; R.sub.2 is of the formula: ##STR2## wherein n is an integer ranging from 1 to 8; R.sub.5 is H or (CH.sub.2).sub.p, wherein p is an integer ranging from 1 to 8; and R.sub.6 is H or (CH.sub.2).sub.m OH, wherein m is an integer ranging from 1 to 8; R.sub.3 is of the formula: --(CH.sub.2).sub.q C.sub.6 H.sub.4 --R.sub.7 wherein q is an integer ranging from 1 to 8; and wherein R.sub.7 is selected from the group consisting of H, NH.sub.2, (CH.sub.2).sub.t OH, wherein t is an integer ranging from 1 to 8; and R.sub.9 COOH, wherein R.sub.9 is an alkyl or alkylidene group having 1 to 8 carbon atoms; and R.sub.4 is of the formula: ##STR3## wherein R.sub.8 is selected from the group consisting of H; NH.sub.2 ; (CH.sub.2).sub.s OH, wherein s is an integer ranging from 1 to 8; and R.sub.10 COOH, wherein R.sub.10 is an alkyl or alkylidene group having 1 to 8 carbon atoms; and r is an integer ranging from 1 to 8.

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