Medical devices with long term non-thrombogenic coatings
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United States of America Patent
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Sep 19, 2000
Issued Date -
N/A
app pub date -
Jun 13, 1996
filing date -
Apr 19, 1995
priority date (Note) -
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Abstract
A coating and method for implantable open lattice metallic stent prostheses are disclosed. The coating includes a relatively thin layer of biostable elastomeric material containing an amount of biologically active material, particularly heparin, dispersed in the coating in combination with a non-thrombogenic surface. In one embodiment, the surface is provided with sites of high electronegativity species by coating with fluorosilicone which aid in controlling elution, particularly the initial release rate, and reduced thrombogenic activity. Other non-thrombogenic outer layers for heparin such as covalently bound polyethylene glycol (PEG) are also disclosed.
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