5-oxoprolinase
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United States of America Patent
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Sep 19, 2000
Grant Date -
N/A
app pub date -
Dec 9, 1996
filing date -
Dec 9, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention is directed to isolated nucleic acid molecules encoding mammalian 5-oxoprolinase (m 5-OPase). Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for increasing or decreasing the expression of m 5-OPase in host cells. The invention further provides a method of screening a substance for the ability of the substance to modify m 5-OPase function, and a method for isolating other m 5-OPase molecules. DNA oligomers and antibodies specific for m 5-OPase are provided, each of which can be used to detect m 5-OPase in a sample.
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