US Patent No: 6,124,269

Number of patents in Portfolio can not be more than 2000

2-Halo-6-O-substituted ketolide derivatives

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Importance

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Abstract

Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ABBOTT LABORATORIESABBOTT PARK, IL2612

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Yan Santa Clara, CA 192 713
Chu, Daniel T Santa Clara, CA 56 669
Clark, Richard F Eden, NY 37 262
Or, Yat Sun Watertown, MA 287 1575
Phan, Ly Tam Quincy, MA 73 287
Platter, Jacob J Berkeley, CA 1 50

Cited Art

Patent Info (Count) # Cites Year
 
TAISHO PHARMACEUTICAL CO., LTD. (3)
4,990,602 Erythromycin A derivatives 66 1988
5,403,923 6-0-methylerythromycin A derivatives 36 1993
5,631,355 5-O-desosaminylerythronolide a derivatives 30 1994
 
AVENTIS PHARMA S.A. (2)
5,444,051 Erythromycin compounds 62 1993
5,747,467 Erythromycins 33 1996
 
ABBVIE INC. (1)
5,866,549 6-O-substituted ketolides having antibacterial activity 90 1997

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ENANTA PHARMACEUTICALS, INC. (25)
6,440,942 14-membered macrolides derived from leucomycins 7 2000
6,436,906 9-amino-14-membered macrolides derived from leucomycins 7 2001
6,753,318 6,11-4-carbon bridged erythromycin derivatives 3 2002
6,727,229 11,12-substituted lactone ketolide derivatives having antibacterial activity 0 2002
6,645,941 6,11-3C-bicyclic 9a-azalide derivatives 13 2003
6,878,691 6-11 bicyclic ketolide derivatives 23 2003
7,129,221 6,11-bicyclic erythromycin derivatives 6 2003
6,790,835 Bicyclic macrolide derivatives 0 2003
6,774,115 6-O-substituted bicyclic ketolides 0 2003
6,765,016 Bicyclic ketolide derivatives 0 2003
6,716,820 6-O-substituted bicyclic macrolides 0 2003
6,764,998 6,11-4C-bicyclic 9a-azalide derivatives 14 2003
7,064,110 6-11 bicycle ketolide derivatives 6 2003
7,022,679 Processes for the preparation of 6-11 bicyclic erythromycin derivatives 5 2004
7,910,558 Bridged macrocyclic compounds and processes for the preparation thereof 0 2004
7,049,417 6,11-4-Carbon bridged ketolides 3 2004
7,276,487 9a, 11-3C-bicyclic 9a-azalide derivatives 0 2004
7,414,030 6-11 Bicyclic erythromycin derivatives 4 2005
7,265,094 9N-substituted 6-11 bicyclic erythromycin derivatives 3 2005
7,273,853 6-11 bicyclic ketolide derivatives 12 2005
7,189,704 6-11 bicyclic ketolide derivatives 5 2005
7,135,573 Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine 6 2005
8,273,720 6,11-bicyclolides: bridged biaryl macrolide derivatives 0 2009
8,354,383 6,11-bridged biaryl macrolides 0 2009
8,383,785 Anti-bacterial activity of 9-hydroxy derivatives of 6,11-bicyclolides 0 2009
 
KOSAN BIOSCIENCES, INC. (10)
6,451,768 Macrolide antiinfective agents 5 2000
6,395,710 Macrolide antiinfective agents 10 2000
6,514,944 Macrolide antiinfective agents 6 2000
6,593,302 Macrolide antiinfective agents 5 2002
6,794,366 Macrolide antiinfective agents 2 2002
6,939,861 Amido macrolides 1 2003
6,762,168 Macrolide antiinfective agents 4 2003
8,063,021 Ketolide anti-infective compounds 0 2004
RE39836 Macrolide antinfective agents 0 2005
7,595,300 7-quinolyl ketolide antibacterial agents 0 2006
 
ABBVIE INC. (3)
6,455,680 Methods utilizing aryl thioimines in synthesis of erythromycin derivatives 2 2000
7,071,314 Arylation method for the functionalization of O-allyl erythromycin derivatives 0 2002
6,998,390 Oxolide antibacterials 1 2003
 
ORTHO-MCNEIL PHARMACEUTICAL, INC. (3)
6,458,771 Ketolide antibacterials 6 2000
6,399,582 Ketolide antibacterials 32 2000
6,590,083 Ketolide antibacterials 7 2000
 
AVENTIS PHARMA S.A. (2)
6,352,983 2-halogenated derivatives of 5-0 desosaminyl-erythronolide A, their preparation process and their antibiotic use 1 1999
RE39743 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use 0 2002
 
CLEMSON UNIVERSITY (2)
7,071,288 Terpolymers from lactide 2 2004
7,754,826 Copolymers from lactide 0 2006
 
CHIRON CORPORATION (1)
7,163,924 Ketolide derivatives 1 2004
 
ENANRA PHARMACEUTICALS, INC. (1)
6,841,664 6,11-4-carbon bridged ketolides 2 2002
 
ENANTA PHARMACEUTICALS (1)
6,720,308 Anhydrolide derivatives having antibacterial activity 2 2002
 
PFIZER PRODUCTS INC. (1)
6,809,080 Macrolide antibiotics 0 2001
 
PLIVA D.D. (1)
6,900,183 Macrolide antibiotics 1 2001