2-Halo-6-O-substituted ketolide derivatives

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6124269
SERIAL NO

09154294

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Abstract

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Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ABBOTT LABORATORIESABBOTT PARK, IL, US924

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Yan Grayslake, IL 293 2739
Chu, Daniel T Santa Clara, CA 56 742
Clark, Richard F Mundelein, IL 43 374
Or, Yat Sun Libertyville, IL 276 3676
Phan, Ly Tam Park City, IL 74 375
Platter, Jacob J Berkeley, CA 1 52

Cited Art Landscape

Patent Info (Count) # Cites Year
 
AVENTIS PHARMA S.A. (2)
* 5444051 Erythromycin compounds 74 1993
* 5747467 Erythromycins 45 1996
 
TAISHO PHARMACEUTICAL CO., LTD. (3)
* 4990602 Erythromycin A derivatives 76 1988
* 5403923 6-0-methylerythromycin A derivatives 37 1993
* 5631355 5-O-desosaminylerythronolide a derivatives 31 1994
 
ABBVIE INC. (1)
* 5866549 6-O-substituted ketolides having antibacterial activity 94 1997
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
PALUMED S.A. (1)
* 2007/0060,558 Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents 11 2006
 
Other [Check patent profile for assignment information] (3)
* 2002/0111,319 2-halogenated derivatives of 5-0-desosaminyl-erythronolide A, their preparation process and their antibiotic use 0 2002
* 2004/0220,120 Novel anhydrolide derivatives having antibacterial activity 0 2004
* 2004/0266,998 6,11-4-Carbon bridged ketolides 0 2004
 
ENANTA PHARMACEUTICALS (1)
6720308 Anhydrolide derivatives having antibacterial activity 2 2002
 
Enanra Pharmaceuticals, Inc. (1)
6841664 6,11-4-carbon bridged ketolides 2 2002
 
ABBOTT LABORATORIES (1)
* 2004/0014,690 Macrolides with activity against methicillin-resistant staphylococcus aureus 5 2003
 
ENANTA PHARMACEUTICALS, INC. (36)
6440942 14-membered macrolides derived from leucomycins 7 2000
6436906 9-amino-14-membered macrolides derived from leucomycins 7 2001
6753318 6,11-4-carbon bridged erythromycin derivatives 3 2002
6727229 11,12-substituted lactone ketolide derivatives having antibacterial activity 0 2002
6645941 6,11-3C-bicyclic 9a-azalide derivatives 13 2003
6878691 6-11 bicyclic ketolide derivatives 27 2003
7129221 6,11-bicyclic erythromycin derivatives 9 2003
6790835 Bicyclic macrolide derivatives 0 2003
6774115 6-O-substituted bicyclic ketolides 0 2003
6765016 Bicyclic ketolide derivatives 1 2003
6716820 6-O-substituted bicyclic macrolides 0 2003
6764998 6,11-4C-bicyclic 9a-azalide derivatives 14 2003
7064110 6-11 bicycle ketolide derivatives 6 2003
7022679 Processes for the preparation of 6-11 bicyclic erythromycin derivatives 7 2004
* 2004/0171,818 Processes for the preparation of 6-11 bicyclic erythromycin derivatives 0 2004
7910558 Bridged macrocyclic compounds and processes for the preparation thereof 0 2004
* 2005/0009,761 Bridged macrocyclic compounds and processes for the preparation thereof 13 2004
7049417 6,11-4-Carbon bridged ketolides 3 2004
7276487 9a, 11-3C-bicyclic 9a-azalide derivatives 0 2004
7414030 6-11 Bicyclic erythromycin derivatives 4 2005
7265094 9N-substituted 6-11 bicyclic erythromycin derivatives 3 2005
* 2005/0171,033 9N-substituted 6-11 bicyclic erythromycin derivatives 0 2005
7273853 6-11 bicyclic ketolide derivatives 17 2005
* 2005/0159,370 English Title Not Available 0 2005
7189704 6-11 bicyclic ketolide derivatives 5 2005
7135573 Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine 7 2005
* 2009/0118,506 6,11-BRIDGED BIARYL MACROLIDES 6 2008
* 2009/0075,915 6,11-BICYCLOLIDES: BRIDGED BIARYL MACROLIDE DERIVATIVES 6 2008
8273720 6,11-bicyclolides: bridged biaryl macrolide derivatives 0 2009
8354383 6,11-bridged biaryl macrolides 0 2009
* 2009/0264,380 6,11-BRIDGED BIARYL MACROLIDES 4 2009
8552162 Processes for the preparation of 2 fluoro 6-11 bicyclic erythromycin derivatives 0 2009
8383785 Anti-bacterial activity of 9-hydroxy derivatives of 6,11-bicyclolides 0 2009
* 2009/0281,050 ANTI-BACTERIAL ACTIVITY OF 9-HYDROXY DERIVATIVES OF 6,11-BICYCLOLIDES 0 2009
* 2009/0281,293 PROCESSES FOR THE PREPARATION OF 2 FLUORO 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES 1 2009
9242974 Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives 0 2013
 
CHIRON CORPORATION (2)
7163924 Ketolide derivatives 9 2004
* 2005/0153,905 Novel ketolide derivatives 11 2004
 
Ortho-McNeil Pharmaceutical, Inc. (3)
6458771 Ketolide antibacterials 6 2000
6399582 Ketolide antibacterials 32 2000
6590083 Ketolide antibacterials 7 2000
 
ABBVIE INC. (3)
6455680 Methods utilizing aryl thioimines in synthesis of erythromycin derivatives 2 2000
7071314 Arylation method for the functionalization of O-allyl erythromycin derivatives 0 2002
* 6998390 Oxolide antibacterials 1 2003
 
PLIVA D.D. (2)
6900183 Macrolide antibiotics 1 2001
* 2004/0082,526 Macrolide antibiotics 0 2003
 
KOSAN BIOSCIENCES, INC. (12)
6451768 Macrolide antiinfective agents 5 2000
6395710 Macrolide antiinfective agents 21 2000
6514944 Macrolide antiinfective agents 6 2000
6593302 Macrolide antiinfective agents 5 2002
6794366 Macrolide antiinfective agents 2 2002
* 6939861 Amido macrolides 1 2003
* 2003/0199,458 Amido macrolides 0 2003
6762168 Macrolide antiinfective agents 4 2003
8063021 Ketolide anti-infective compounds 0 2004
* 2005/0272,672 Ketolide anti-infective compounds 0 2004
RE39836 Macrolide antinfective agents 1 2005
7595300 7-quinolyl ketolide antibacterial agents 0 2006
 
PFIZER PRODUCTS INC. (1)
6809080 Macrolide antibiotics 0 2001
 
AVENTIS PHARMA S.A. (2)
* 6352983 2-halogenated derivatives of 5-0 desosaminyl-erythronolide A, their preparation process and their antibiotic use 1 1999
* RE39743 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use 0 2002
 
Far East Medical, LLC (1)
* 2005/0125,885 Foldable toilet-sitting appliance 0 2004
 
CLEMSON UNIVERSITY (3)
7071288 Terpolymers from lactide 2 2004
* 2005/0004,338 Novel terpolymers from lactide 1 2004
7754826 Copolymers from lactide 1 2006
* Cited By Examiner